dAURK-4 hydrochloride

SKU: orb1983210

Description

dAURK-4 hydrochloride is a selective degrader of the Aurora A kinase (AURKA), demonstrating antiproliferative and anticancer activity. It is utilized in cancer research to study targeted protein degradation and has been evaluated in both cellular and animal models of oncology.

Research Area

Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• MW: 1071.93
• Purity: 99.44% (May vary between batches)
• Formula: C₅₂H₅₃Cl₂FN₈O₁₂
• SMILES: O=C(C1=CC=C(NC2=NC(C3=C(C(C4=C(OC)C=CC=C4F)=NC5)C=C(Cl)C=C3)=C5C=N2)C=C1OC)NCCCOCCOCCOCCCNC(COC6=CC=CC(C(N7C8C(NC(CC8)=O)=O)=O)=C6C7=O)=O.Cl
• Target: PROTACs,Aurora Kinase

Bioactivity

• In Vitro:
  In MM.1S cells, dAURK-4 hydrochloride (125 nM, 250 nM, 500 nM, 1000 nM; 4 hours or 24 hours) inhibited the protein level of AURKA (Aurora A).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

dAURK-4 hydrochloride (2705844-81-9 free base), AuroraKinase, Aurora Kinase, Aurora A

Compound Identifiers

PubChem CID

163196236