Dauricine

SKU: orb1222111

Description

Dauricine has pulmonary toxicity, can produce pulmonary injury in CD-1 mice by the metabolism of Dauricine mediated by CYP3A. Dauricinec can pass the blood-brain barrier, and that P-glycoprotein has an important role in the transportation of Dauricine across the blood-brain barrier. Dauricine may has anti-tumor effect, can inhibit tumor cells in urinary system and colon cancer cell proliferation, invasion; induce cell apoptosis by suppressing NF-kappaB activity and the expression profile of its downstream genes.

Key Properties

• CAS Number: 524-17-4
• MW: 624.77
• Purity: >98% (HPLC)
• Formula: C₃₈H₄₄N₂O₆
• SMILES: CN1CCC2=CC(=C(C=C2C1CC3=CC=C(C=C3)OC4=C(C=CC(=C4)CC5C6=CC(=C(C=C6CCN5C)OC)OC)O)OC)OC
• Target: PPAR
• Solubility: In Vitro: DMSO : 100 mg/mL (160.06 mM)

Bioactivity

• In Vivo:
  Animal model: HCT116 xenograft mouse model. Dosage: 40 mg/kg. Administration: s. c. , every 2-day. for 9 days. Result: Inhibited colonic tumor growth completely at 9 days, with little effect on body weight.
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• In Vitro:
  Apoptosis Analysis Cell line: HCT 116. Concentration: 5, 10, 20 μM. Incubation time: 36 h. Result: Showed he percentages of apoptotic rate of 7.8% to 14.4%, 19.8%, and 29.7% at 5, 10, and20 μM. Increased the accumulation of cleavage PARP and caspase3. Western blot analysis. Cell line: HCT 116. Concentration: 5, 10, 20 μM. Incubation time: 36 h. Result: Inhibited the TNF (0.5 nM)-induced phosphorylation and nuclear translocation of p65.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PPAR