Datelliptium chloride

SKU: orb1220329

Description

Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.

Key Properties

• CAS Number: 105118-14-7
• MW: 397.94
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₈ClN₃O
• SMILES: CCN(CC)CC[n+]1ccc2c(C)c3[nH]c4ccc(O)cc4c3c(C)c2c1.[Cl-]
• Target: DNA/RNA Synthesis
• Solubility: H2O:41.67 mg/mL (104.71 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Upon intravenous administration, datelliptium acetate shows potent inhibitory activities In vivo against a variety of murine solid tumors. Datelliptium acetate is highly active against early-stage colon #38 with highest non-toxic dose (HNTD) of 170 mg/kg TD, and weight loss of 10%, T/C of 0%.
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• In Vitro:
  Datelliptium (100 μM) shows significantly cytotoxic effects after 2 hr of treatment in suspension and primary cultures of rat hepatocytes. Datelliptium mobilizes glycogen in both rat systems in vitro concentration dependently. The half-maximal effect is 14.3 μM in isolated hepatocytes, whereas in cultured rat hepatocytes it is 5.9 μM. Datelliptium also leads to a concentration-dependent decrease in gluconeogenesis from lactate in cells. Datelliptium acetate is selectively cytotoxic for solid tumors over leukemia L1210. Human tumors H-125 and HCT-116 demonstrates less sensitivity to datelliptium acetate.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DNA/RNA Synthesis