Darolutamide

SKU: orb1300350

Description

Darolutamide

Research Area

Metabolism Research

Key Properties

• CAS Number: 1297538-32-9
• MW: 398.85
• Purity: 99.14%
• Formula: C₁₉H₁₉ClN₆O₂
• SMILES: C[C@@H](Cn1ccc(n1)-c1ccc(C#N)c(Cl)c1)NC(=O)c1cc([nH]n1)C(C)O
• Target: Androgen Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.01 mM);DMSO:122.5 mg/mL (307.13 mM);Ethanol:36 mg/mL (90.26 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  Androgen receptor:11 nM(Ki)
• In Vivo:
  In mice bearing VCaP xenografts, ODM-201 (50 mg/kg, p.o.) significantly inhibits castration-resistant prostate tumor growth.
• In Vitro:
  In AR-HEK293 cells stably expressing full-length hAR, ODM-201 inhibits human AR (hAR) with IC50 of 26 nM. ODM-201 inhibits VCaP cell proliferation with IC50 of 230 nM, while has no effect on the viability of AR-negative cell lines tested, DU-145 prostate cancer cells and H1581 lung cancer cells.
• Cell Research:
  VCaP cells are treated with a submaximal concentration of mibolerone (0.1 nM) and increasing concentrations of test compounds in steroid-free assay medium supplemented with 4 mM GlutaMAX. After a 4-day incubation with the compounds, cell viability is measured using a WST-1 cell proliferation assay. To rule out non-AR –mediated toxicity, AR-negative PC cells (DU-145) and lung cancer cells (H1581) are treated with an increasing concentration of ODM-201, and cell viability is measured as described above.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, ODM 201, ODM201, ODM-201, Inhibitor, Androgen Receptor, AndrogenReceptor, BAY1841788, BAY-1841788, BAY 1841788, Darolutamide

Compound Identifiers

PubChem CID

67171867