Darizmetinib

SKU: orb1980154

Description

Darizmetinib (HRX215) is a selective MKK4 inhibitor whose mechanism involves enhancing MKK7-JNK1 signaling to activate transcription factors like ATF2 and ELK1, thereby promoting hepatocyte proliferation. This activity supports its research use in studying liver regeneration and related disease models in both cellular and preclinical contexts.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 2369583-33-3
• MW: 457.45
• Purity: 99.57%
• Formula: C₂₁H₁₇F₂N₅O₃S
• SMILES: O=C(C1=NNC2=NC=C(C=C21)C=3C=CN=CC3)C4=CC=C(F)C(NS(=O)(=O)CCC)=C4F
• Target: JNK,MDM-2/p53,MAPK,Antiviral,p38 MAPK,NF-κB
• Solubility: DMSO:180 mg/mL (393.49 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  MAP2K4:< 500 nM|MKK4:0.02 µM

Storage & Handling

• Storage: keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antiviral, MAP2K, HRX-0215, HRX215

Compound Identifiers

PubChem CID

139369660