Dapivirine

SKU: orb1307391

Description

Dapivirine

Research Area

Cell Biology, Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 244767-67-7
• MW: 329.4
• Purity: 99.47%
• Formula: C₂₀H₁₉N₅
• SMILES: N(C1=C(C)C=C(C)C=C1C)C2=NC(NC3=CC=C(C#N)C=C3)=NC=C2
• Target: Autophagy,Reverse Transcriptase,HIV Protease,Apoptosis
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (6.07 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:32 mg/mL (97.15 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  HIV RT:24 nM
• In Vivo:
  Dapivirine-containing gel at vaginal level inhibits cell-associated HIV infection in mice. More placebo (7 of 12) than Dapivirine (3 of 24) gel users has positive vaginal swab results, with white blood cells being the most common finding. Dapivirine (0.05%) results in Cmax of 715 pg/mL, AUC of 15 ng×h/mL and T1/2 of 89.87 hours in plasma after 14 days post-dose. Mean Dapivirine (0.05%) concentrations in vaginal fluids collected at the introitus, mid vagina, and cervix are in the range of 62-265 μg/g on day 1.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Human immunodeficiency virus, Inhibitor, HIV, HIVProtease, HIV Protease, HIV reverse transcriptase, inhibit, Apoptosis, Autophagy, Dapivirine, TMC120, TMC-120, TMC 120, R 147681, R147681, R-147681, ReverseTranscriptase, Reverse Transcriptase

Compound Identifiers

PubChem CID

214347