Dapagliflozin ((2S)-1,2-propanediol, hydrate)

SKU: orb1302841

Description

Dapagliflozin propanediol monohydrate is a selective, orally active SGLT2 inhibitor developed for type 2 diabetes research. It blocks renal glucose reabsorption and is widely used in both in vitro binding assays and in vivo models of diabetes and heart failure to study metabolic and cardiovascular effects.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 960404-48-2
• MW: 502.98
• Purity: 99.94% (May vary between batches)
• Formula: C₂₄H₃₅ClO₉
• SMILES: O.O[C@H]1[C@H](O)[C@@H](O)[C@@H](O[C@@H]1CO)c3ccc(Cl)c(Cc2ccc(OCC)cc2)c3.C[C@H](O)CO
• Target: SGLT
• Solubility: DMSO:50 mg/mL (99.41 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.98 mM)

Bioactivity

• Target IC50:
  SGLT2:
• In Vitro:
  Dapagliflozin (2S)-1,2-propanediol, hydrate is the S-enantiomer of Dapagliflozin 1,2-propanediol, hydrate. Dapagliflozin inhibits sodium/glucose cotransporter 2 (SGLT2), which results in excretion of glucose into the urine.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dapagliflozin ((2S) 1,2 propanediol, hydrate), Dapagliflozin ((2S)1,2propanediol, hydrate), Dapagliflozin (1,2-propanediol, hydrate), Dapagliflozin propanediol, Dapagliflozin propanediol Monohydrate, Dapagliflozin propanediol monohydrate, BMS-512148 (2S)-1,2-propanediol, hydrate, BMS-512148 1,2-propanediol, Hydrate, Inhibitor, inhibit, Sodium-dependent glucose cotransporters, SGLT2, SGLT

Compound Identifiers

PubChem CID

24906252