Dantrolene sodium hemiheptahydrate

SKU: orb1303229

Description

Dantrolene sodium is a hydantoin-derived muscle relaxant that inhibits skeletal muscle contraction by binding to the ryanodine receptor 1 (RyR1), thereby reducing calcium release from the sarcoplasmic reticulum. It is widely used in research applications, including in vitro studies of excitation-contraction coupling and in vivo models of malignant hyperthermia and muscle spasticity.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 24868-20-0
• MW: 399.29
• Purity: 99.72%
• Formula: C₁₄H₉N₄NaO₅·3.5H₂O
• SMILES: O.O.O.O.O.O.O.[NaH].[NaH].[O-][N+](=O)c1ccc(cc1)-c1ccc(C=NN2CC(=O)NC2=O)o1.[O-][N+](=O)c1ccc(cc1)-c1ccc(C=NN2CC(=O)NC2=O)o1
• Target: Apoptosis,Autophagy,ROS,Calcium Channel
• Solubility: DMSO:16.67 mg/mL (41.75 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (1.25 mM)

Bioactivity

• In Vivo:
  In contrast of the slow soleus (SOL) muscle, Dantrolene sodium (5 mg/kg) has a greater inhibitory on the twitch contraction of the fast extensor digitorum longus (EDL) muscle.
• In Vitro:
  Dantrolene sodium can inhibit intracellular Ca2+ release from the sarcoplasmic reticulum. In the linoleic acid emulsion system, Dantrolene sodium has strong antioxidant activity.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Dantrolene sodium, Dantrolene sodium hemiheptahydrate, Dantrolene sodium Hydrate, Dantrolene sodium hydrate, Dantrolene sodium salt, Dantrium, CalciumChannel, Autophagy, Ca channels, Ca2+ channels, Calcium Channel, Sodium dantrolene

Compound Identifiers

PubChem CID

176418233