Daniquidone

SKU: orb1740584

Description

Daniquidone (Batracylin) is a dual topoisomerase I/II inhibitor that induces DNA fragmentation and exhibits cytotoxic effects. It is used in research to study cancer, immune disorders, and lymphatic diseases, with applications in both in vitro cell-based assays and in vivo experimental models.

Research Area

Molecular Biology

Key Properties

• CAS Number: 67199-66-0
• MW: 249.27
• Purity: 99.52% (May vary between batches)
• Formula: C₁₅H₁₁N₃O
• SMILES: O=C1N2C(C=3C1=CC=CC3)=NC=4C(C2)=CC(N)=CC4
• Target: Topoisomerase

Bioactivity

• Target IC50:
  HT29 cells:10.02 µM
• In Vitro:
  Daniquidone (0-300 µM; 6 hours) exhibits cytotoxicity against HT29 cells, with an IC50 value of 10.02 µM. Additionally, Daniquidone (100, 300 µM;3 hours) can induce protein-linked DNA breaks consistent with topoisomerase targeting.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 320846, BAY-H 2049, Daniquidone, topoisomerase I, topoisomerase II

Compound Identifiers

PubChem CID

71750