Dabrafenib Mesylate

SKU: orb1220071

Description

Dabrafenib Mesylate is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).In human endothelial cells, Dabrafenib inhibits the release of HMGB1 and down-regulates the HMGB1-dependent inflammatory response by enhancing the expression of cell adhesion molecules (CAM).

Key Properties

• CAS Number: 1195768-06-9
• MW: 615.67
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₄F₃N₅O₅S₃
• SMILES: CS(O)(=O)=O.CC(C)(C)C1=NC(=C(S1)C1=NC(N)=NC=C1)C1=C(F)C(NS(=O)(=O)C2=C(F)C=CC=C2F)=CC=C1
• Target: Raf
• Solubility: DMSO:34 mg/mL (55.22 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK2118436 Mesylate,GSK 2118436B

Quick Database Links

Gene Symbol

Raf