Dabigatran

SKU: orb1225680

Description

A reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM; an anticoagulant agent used to prevent stroke with atrial fibrillation.Thrombosis Approved(In Vitro):Dabigatran (BIBR 953) shows concentration-dependent anticoagulant effects in various species in vitro, doubling the activated partial thromboplastin time (aPTT), prothrombin time (PT) and ecarin clotting time (ECT) in human platelet-poor plasma at concentrations of 0.23, 0.83 and 0.18 μM, respectively.(In Vivo):Dabigatran (0.01-0.1 mg/kg; i.v.) inhibits clot formation with an ED50 of 0.033 mg/kg in Wessler model.

Key Properties

• CAS Number: 211914-51-1
• MW: 471.5111
• Purity: >98% (HPLC)
• Formula: C₂₅H₂₅N₇O₃
• SMILES: CN1C2=C(C=C(C=C2)C(=O)N(CCC(=O)O)C3=CC=CC=N3)N=C1CNC4=CC=C(C=C4)C(=N)N
• Target: Thrombin
• Solubility: DMSO: < 1 mg/mL; H2O: < 1 mg/mL

Bioactivity

• In Vivo:
  Dabigatran (0.01-0.1 mg/kg; i. v.) inhibits clot formation with an ED50 of 0.033 mg/kg in Wessler model. Animal model: Male rats (Wessler model). Dosage: 0.01, 0.03, 0.05 and 0.1 mg/kg. Administration: Intravenous injection. Result: Inhibited clot formation with an ED50 of 0.033 mg/kg.
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• In Vitro:
  Dabigatran (BIBR 953) shows concentration-dependent anticoagulant effects in various species in vitro, doubling the activated partial thromboplastin time (aPTT), prothrombin time (PT) and ecarin clotting time (ECT) in human platelet-poor plasma at concentrations of 0.23, 0.83 and 0.18 μM, respectively.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BIBR 953 | BIBR 953ZW | BIBR953 | BIB-953

Quick Database Links

Gene Symbol

Thrombin