Dabigatran etexilate

SKU: orb1310659

Description

Dabigatran etexilate is a direct thrombin inhibitor prodrug used in research to study anticoagulation. It is applied in vitro to assess thrombin activity and in vivo within animal models of thrombosis, aiding cardiovascular and hematological research.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 211915-06-9
• MW: 627.73
• Purity: 99.98% (May vary between batches)
• Formula: C₃₄H₄₁N₇O₅
• SMILES: CCCCCCOC(=O)N\N=C\c1ccc(NCc2nc3cc(ccc3n2C)C(=O)N(CCC(=O)OCC)c2ccccn2)cc1
• Target: Thrombin
• Solubility: DMSO:116 mg/mL (184.79 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.37 mM);Ethanol:10 mg/mL (15.93 mM)

Bioactivity

• Target IC50:
  DTI:4.5 nM (Ki)
• In Vivo:
  Dabigatran has a concentration-dependent anticoagulant effect in various animals.Dabigatran reversibly inhibits human thrombin (Ki: 4.5 nM) and thrombin-induced platelet aggregation (IC50= 10 nM).
• In Vitro:
  Dabigatran has a concentration-dependent anticoagulant effect in various animals.Dabigatran reversibly inhibits human thrombin (Ki: 4.5 nM) and thrombin-induced platelet aggregation (IC50= 10 nM).

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dabigatran etexilate, Dabigatran, BIBR1048, BIBR-1048, BIBR 1048, anticoagulant, antithrombotic, atrial, active, agent, inhibit, orally, effects, fibrillation, Inhibitor, Thrombin, prodrug, venousthromboembolism

Compound Identifiers

PubChem CID

23120632