D609

SKU: orb1707404

Description

D609 is a broad-spectrum bioactive small molecule known for its antioxidant, antitumor, and neuroprotective properties. It functions as a competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC) and sphingomyelin synthase (SMS), making it a valuable research tool for studying lipid signaling, apoptosis, and inflammation in both cellular and animal models.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 83373-60-8
• MW: 266.46
• Purity: 99.56%
• Formula: C₁₁H₁₅KOS₂
• SMILES: S=C(OC1CC2CC1C3CCCC23)S[K]
• Target: Phospholipase,Apoptosis,Antioxidant
• Solubility: H2O:1 mg/mL (3.75 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (9.38 mM);DMSO:80 mg/mL (300.23 mM)

Bioactivity

• Target IC50:
  PC-PLC:6.4 μM (Ki)
• In Vivo:
  D609 (2.5 and 10 mg/kg/day; intraperitoneal injection; continuous for 6 weeks) inhibits the progression of pre-existing atherosclerotic lesions in apoE-/- mice and transforms the lesion composition into a more stable phenotype.Pre-treatment with D609 (50 mg/kg; intraperitoneal injection; single dose) 30 minutes before intratracheal administration of LPS (3 mg/kg) prevents lipopolysaccharide-induced pulmonary arterial hypertension in adult male Wistar rats.
• In Vitro:
  D609 (100 μM; 2 hours) significantly inhibits the proliferation of various cell lines.At concentrations of 50, 100, and 200 μM (2 hours), D609 activates caspase-3 at 200 μM, while at 50 and 100 μM, no detectable cleavage is observed.D609 (100 μM; 2 hours) markedly inhibits BrdU incorporation in BV-2 microglial cells, leading to G1 phase cell accumulation and a decrease in the number of cells in the S phase.D609 (100 μM; 2 hours, followed by 2 or 22 hours of cultivation without D609) increases ceramide levels, upregulates p21 expression, and results in decreased phosphorylation of Rb.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antioxidant, Apoptosis, D 609, D609, D-609, PC-PLC

Compound Identifiers

PubChem CID

4234241