D359-0396

SKU: orb1942149

Description

D359-0396 is a potent, orally bioavailable NLRP3 inflammasome inhibitor that blocks NLRP3-ASC oligomerization and GSDMD cleavage, suppressing pyroptosis and IL-1β secretion in macrophages. It demonstrates efficacy in preclinical models, including reducing severity in Experimental Autoimmune Encephalomyelitis (EAE) and improving survival in murine septic shock.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 1031977-31-7
• MW: 400.47
• Formula: C₂₄H₂₄N₄O₂
• SMILES: O=C1C2=CN3C=4C=CC=CC4NC(C5=CC=C(C=C5)C(C)C)C3=C2N(C(=O)N1C)C
• Target: NOD-like Receptor (NLR),Pyroptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

46265697