D3-βArr

SKU: orb1301837

Description

D3-βArr (NCGC00379308) is a small molecule positive allosteric modulator of the thyrotropin receptor (TSHR). Its direct activation of TSHR induces β-arrestin 1 translocation with an EC50 of 11.6 µM, making it a useful research tool for studying TSHR signaling and related GPCR pathways in cellular models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 662164-09-2
• MW: 333.43
• Purity: 99.43% (May vary between batches)
• Formula: C₂₀H₂₃N₅
• SMILES: CC(Nc1nc(nc2ccccc12)N1CCNCC1)c1ccccc1
• Target: TSH Receptor
• Solubility: DMSO:100 mg/mL (299.91 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (12 mM)

Bioactivity

• Target IC50:
  TSHR:11.6 μM(EC50)
• In Vitro:
  D3-βArr stimulated β-Arr 1 translocation with an efficacy threefold greater than TSH. The EC50 for β-Arr 1 translocation by D3-βArr was 11.6 μM. D3-βArr (10 μM) increased the efficacy of TSH in the translocation of β-Arr 1 at a maximum of 5.1-fold over TSH alone.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

D3 βArr, D3-bArr, D3-betaArr, D3βArr, D-3-βArr, D3-βArr, Inhibitor, inhibit, NCGC00379308, NCGC-00379308, NCGC 00379308, Thyrotropin receptor, thyrotropin receptor (TSHR), Thyroid-stimulating hormone Receptor, TSH Receptor, TSHReceptor

Compound Identifiers

PubChem CID

2950121