D18

SKU: orb1688646

Description

D18 is a dual TLR7/8 agonist (EC50: 24 nM hTLR7, 10 nM hTLR8) that epigenetically upregulates PD-L1 to potentiate anti-PD-1/PD-L1 therapy. It also serves as a cytotoxic payload for antibody-drug conjugates (ADCs), such as HE-S2, supporting research in immuno-oncology and ADC development [1].

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 2230218-36-5
• MW: 364.49
• Formula: C₂₁H₂₈N₆
• SMILES: N(CCCC)C=1C2=C(C=CC(CC3=CC=C(CN(C)C)C=C3)=N2)N=C(N)N1
• Target: Others,PD-1/PD-L1,TLR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

147429730