D-Pantethine

SKU: orb1225973

Description

Pantethine is a dimeric form of pantothenic acid, is an intermediate in the production of Coenzyme A, is available as a dietary supplement, and is used to treat acne and improve the blood-cholesterol profile.

Key Properties

• CAS Number: 16816-67-4
• MW: 554.72
• Purity: >98% (HPLC)
• Formula: C₂₂H₄₂N₄O₈S₂
• SMILES: O=C(NCCSSCCNC(CCNC([C@H](O)C(C)(C)CO)=O)=O)CCNC([C@H](O)C(C)(C)CO)=O
• Target: Vitamin
• Solubility: DMSO: ≥ 30 mg/mL; Water: ≥ 80 mg/mL

Bioactivity

• In Vivo:
  Animal model: Male Sprague–Dawley rats model. Dosage: 1.2 mmol/kg. Administration: Intragastrical administration (i. g.); Single dose. Result: Reduced plasma free fatty acid (FFA), cholesterol, and triglyceride levels at 3, 5, 7, and 24 h, while significantly increased glycerol levels at 7 h. Animal model: Orthotopic female rats model of ovarian cancer. Dosage: 750 mg/kg. Administration: Intraperitoneal injection (i.p.); Once daily for 4 weeks. Result: Reduced tumor growth, metastasis and ascites, and had no toxicity to liver and kidney. Animal model: Systemic sclerosis (SSc) BALB/c mice model. Dosage: 15 mg/kg. Administration: Oral gavage (p.o.); Once daily for 6 weeks. After HOCL treatment (200 μM; Intradermal injection; Once daiy for 6 weeks). Result: Decreased the number of MPs in mice endothelial cells. Decreased the concentrations of soluble E-selectin and sVCAM-1 in serum. Decreased serum concentration of AOPPs (33%) and nitrate (60%). Animal model: Ketogenic diet mouse model. Dosage: 150 mg/kg. Administration: Supplemented in daily drinking water, for 2 months. Follow a casual ketogenic diet during this period. Result: Alleviated motor dysfunction, neurodegeneration and changes in mitochondria of the central and peripheral nervous systems in mice.
• In Vitro:
  Western blot analysis. Cell line: Calu-3a, Vero E6. Concentration: 50 μM, 100 μM, 250 μM, 500 μM, 1000 μM. Incubation time: Cell were pretreated with Pantethine for 1 h prior to virus infection, followed by incubation with the virus for 2 h in the presence of Pantethine until the end of the experiment. Result: Decreased the expression of viral spike (S) and nucleocapsid (N) proteins. RT-PCR Cell line: Calu-3a, Vero E6. Concentration: 50 μM, 100 μM, 250 μM, 500 μM, 1000 μM. Incubation time: Cell were pretreated with Pantethine for 1 h prior to virus infection, followed by incubation with the virus for 2 h in the presence of Pantethine until the end of the experiment. Result: Significantly reduced the copy number of viral nucleapsid (N) and non-structural protein 6 (NSP6) genes in the cell supernatant. Decreased the mRNA expression levels of HECT E3 ligase and TMPRSS2 in virus-induced infected cells. Significantly decreased the mRNA expression of MAVS, IRF3, IFNβ, STING, TNF-α and IL6 in Calu-3a cells, and decreased the inflammation caused by SARS-CoV-2 virus infection.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pantethine | LBF disulfide | Lipodel | Pantosin | D-Pantethine

Quick Database Links

Gene Symbol

Vitamin