D-Galactose

SKU: orb1310463

Description

D-Galactose, a C-4 epimer of glucose, is a natural hexose used to form lactose. It is widely employed in research to induce aging models in animals and is utilized in various in vitro studies of carbohydrate metabolism and glycosylation.

Research Area

Metabolism Research

Key Properties

• CAS Number: 59-23-4
• MW: 180.16
• Purity: 99.78%
• Formula: C₆H₁₂O₆
• SMILES: [C@@H]([C@@H]([C@H](C=O)O)O)([C@@H](CO)O)O
• Target: Endogenous Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (18.32 mM);H2O:66 mg/mL (366.34 mM);DMSO:86.6 mg/mL (480.68 mM)

Bioactivity

• In Vivo:
  Chronic D-galactose exposure induces neurodegeneration by enhancing caspase-mediated apoptosis and inhibiting neurogenesis and neuron migration in mice, as well as increasing oxidative damage. Moreover, D-galactose-induced toxicity in mice is a useful model for studyin the mechanisms of neurodegeneration and neur Protective drugs and agent. D-galactose given by oral route leads to cognitive impairments in rats which are accompanied by oxidative damage. Cognitive impairments is observed in the open-ffield test in the 4 h and 6 h weeks after d-gal administration, as well as an impairment in spatial memory in the radial maze test afte the 6 h week of d-gal administratio.
• In Vitro:
  Galactose is important fo the survival and virulence of bacteria. Galactose is utilized b the Leloir pathway in Escherichia coli. Two anomers of d-galactose are used for different purposes, α-d-galactose as a carbon source and β-d-galactose for induction of UDP-galactose synthesis for biosynthetic glycosylatio.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

D-(+)-Galactose, D Galactose, Endogenous Metabolite, D-Galactopyranose, DGalactose, D-Galactose, Alpha-D-galactose, a-D-galactose, EndogenousMetabolite, α-D-galactose

Compound Identifiers

PubChem CID

3037556