D-Erythro-dihydrosphingosine

SKU: orb1710787

Description

This small molecule inhibitor selectively targets cytosolic phospholipase A2 alpha (cPLA2α), blocking its activity and the subsequent release of arachidonic acid. It is a valuable research tool for studying lipid signaling pathways in inflammation and apoptosis, applicable in both cellular and biochemical assay systems.

Research Area

Metabolism Research

Key Properties

• CAS Number: 764-22-7
• MW: 301.51
• Purity: 99.50%
• Formula: C₁₈H₃₉NO₂
• SMILES: CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)CO
• Target: Phospholipase,Endogenous Metabolite
• Solubility: Ethanol:20 mg/mL (66.33 mM);DMSO:10 mg/mL (33.17 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.32 mM)

Bioactivity

• In Vitro:
  In PC12 cells, D-Erythro-dihydrosphingosine inhibits mastoparan-stimulated arachidonic acid release. D-Erythro-dihydrosphingosine (100 μM) slightly inhibits [3H]Arachidonic acid release.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

C18-Dihydrosphingosine, cPLA2α, Dihydrosphingosine, D-Erythro-dihydrosphingosine, D-erythro-Sphinganine, Octadecasphinganine, Human Endogenous Metabolite

Compound Identifiers

PubChem CID

91486