[D-Arg1,D-Trp5,7,9,Leu11]-Substance P

SKU: orb3180507

Description

[D-Arg1,D-Trp5,7,9,Leu11]-Substance P is a potent inhibitor of small cell lung cancer (SCLC) cell growth. As a neuropeptide antagonist, [D-Arg1,D-Trp5,7,9,Leu11]-Substance P effectively blocks colony formation stimulated by multiple neuropeptides such as vasopressin and bradykinin. It inhibits Ca2+ mobilization and mitogen-activated protein kinase activation induced by vasopressin or bradykinin. [D-Arg1,D-Trp5,7,9,Leu11]-Substance P also suppresses the growth of H-69 xenografts in nude mice.

Research Area

Pharmacology & Drug Discovery

Key Properties

• Target: Neurotensin Receptor
• CAS Number: 122481-75-8
• MW: 1555.9
• Formula: C₈₁H₁₁₀N₂₀O₁₂
• SMILES: C([C@@H](NC(=O)[C@H]1N(C([C@@H](NC(=O)[C@H]2N(C([C@@H](CCCNC(=N)N)N)=O)CCC2)CCCCN)=O)CCC1)C(N[C@H](C(N[C@H](CC=3C=4C(NC3)=CC=CC4)C(N[C@@H](CC5=CC=CC=C5)C(N[C@H](CC=6C=7C(NC6)=CC=CC7)C(N[C@H](C(N[C@@H](CC(C)C)C(N)=O)=O)CC(C)C)=O)=O)=O)=O)CCC(N)=O)=O)C=8C=9C(NC8)=CC=CC9

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Neurotensin Receptor