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D-156844 hydrochloride

SKU: orb3173103

Description

D-156844 (Compound 11a) hydrochloride is an SMN2 promoter activator with an EC50 of 4 nM. It enhances mRNA expression of the mouse SMN in NSC-34 cells and the human SMN2 promoter in fibroblasts from patients with severe type I spinal muscular atrophy (SMA), along with increasing full-length human SMN protein expression. D-156844 hydrochloride can overcome DHFR inhibition and is used in SMA research.

Images & Validation

Key Properties

TargetDHFR,DNA/RNA Synthesis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information