CZL-077

SKU: orb3174800

Description

CZL-077 is a potent, highly selective, and orally active p300/CBP bromodomain (BRD) inhibitor, with p300 IC50 at 0.034 μM and CBP IC50 at 0.052 μM, demonstrating strong selectivity for the BRD of BET proteins (BRD2/3/4). This compound effectively inhibits the growth of OPM-2 and 22RV1 cells, with IC50 values of 0.024 μM and 5.6 μM, respectively. In xenograft mouse models of OPM-2 and 22RV1, CZL-077 exhibits anti-tumor activity. CZL-077 is applicable for research in multiple myeloma and prostate cancer.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 3032444-06-4
• MW: 577.63
• Formula: C₃₀H₂₆F₃N₅O₂S
• SMILES: O=C1N([C@H](C=2N(C=3C(N2)=CC(=CC3)C=4C(C)=NOC4C)[C@H]5CC6=C(CC5)N=C(C)S6)C[C@@H]1F)C7=CC(F)=C(F)C=C7
• Target: Epigenetic Reader Domain

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Epigenetic Reader Domain