CZh226 hydrochloride

SKU: orb3175056

Description

CZh226 hydrochloride is a potent and selective inhibitor of PAK4, with an IC50 of 18 nM and a selectivity of 346-fold over PAK1. The oral bioavailability of CZh226 hydrochloride is poor, necessitating the use of the prodrug PAK4-IN-1 to enhance absorption and metabolic stability. It is applicable in research on colorectal cancer and melanoma.

Key Properties

• CAS Number: 2231440-94-9
• MW: 448.35
• Formula: C₂₀H₂₃Cl₂N₇O
• SMILES: N(C=1C2=C(N=C(C(=O)N3C[C@@H](C)NCC3)N1)C=CC(Cl)=C2)C=4C=C(NN4)C5CC5.Cl
• Target: PAK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PAK