Cytisine-platinum(IV) prodrug-1

SKU: orb3211021

Description

Cytisine-Platinum(IV) Prodrug-1 (CP12) is a Pt(IV) prodrug incorporating the natural product cytisine, known for its antiproliferative effects on tumor cells. CP12 facilitates calcium ion transport via the IP3R1-GRP75-VDAC1 axis, causing mitochondrial calcium overload. It initiates the unfolded protein response through PERK, eIF2α, ATF4, and CHOP, regulating Bcl-2 and Bax to induce apoptosis. Additionally, CP12 leads to mitochondrial dysfunction, reactive oxygen species (ROS) production, reduced ATP synthesis, DNA damage, and S-phase cell cycle arrest. It activates the cGAS-STING pathway, decreases PD-L1 expression, and promotes immunogenic cell death. CP12 exhibits high physiological stability, efficient cellular accumulation, and enhanced platinum-DNA binding capacity, suppressing tumor growth with reduced systemic toxicity in mouse models. This compound is useful for lung cancer research.

Key Properties

• Target: PD-1/PD-L1,PERK,ROS,STING,Apoptosis,DNA/RNA Synthesis,Bcl-2 Family

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PD-1/PD-L1,PERK,ROS,STING,Apoptosis,DNA/RNA Synthesis,Bcl-2 Family