Cysmethynil

SKU: orb1694056

Description

Cysmethynil is a time-dependent, indole-based inhibitor of Icmt, disrupting RAS membrane localization and EGF signaling. It induces G1 cell cycle arrest and autophagy, demonstrating antitumor activity in research models. This compound is utilized for studying oncogenic pathways and potential therapeutic interventions in solid tumors.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 851636-83-4
• MW: 376.53
• Purity: 99.17% (May vary between batches)
• Formula: C₂₅H₃₂N₂O
• SMILES: O=C(N)CC1=CN(C2=CC=C(C=C21)C=3C=CC=C(C3)C)CCCCCCCC
• Target: Transferase,Ras,Autophagy
• Solubility: DMSO:2 mg/mL (5.31 mM);Ethanol:20 mg/mL (53.12 mM);DMF:3.3 mg/mL (8.76 mM)

Bioactivity

• In Vivo:
  Cysmethynil(20 mg/kg; intraperitoneal injection; three times per week; 2 weeks) used alone or in combination with Paclitaxel/Doxorubicin) significantly inhibits tumor growth. In a xenograft mouse model, Cysmethynil sensitizes cervical cancer cells to chemotherapy drugs.
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• In Vitro:
  Mouse embryonic fibroblasts grown in medium containing 8% serum were treated with concentrations of 15, 20, or 30 μM of Cysmethynil. The medium and drug were changed daily, and cell growth was monitored for 6 days,The results showed that treatment with Cysmethynil led to dose-dependent inhibition of growth in wild-type cells, while Icmt–/– cells were largely unaffected.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cysmethynil, Autophagy, isoprenylcysteine carboxylmethyltransferase (ICMT), Ras

Compound Identifiers

PubChem CID

6918831