CYP51/PD-L1-IN-3

SKU: orb2277720

Description

CYP51/PD-L1-IN-3 (compound L21), a quinazoline with antifungal properties, serves as a dual inhibitor targeting CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μM). This compound promotes early fungal apoptosis, diminishes intracellular concentrations of IL-2, NLRP3, and NF-κBp65 proteins, incites mitochondrial impairment and ROS accumulation, and culminates in fungal cell lysis and death.

Key Properties

• MW: 468.55
• Formula: C₂₇H₂₈N₆O₂
• Target: Cytochromes P450,Others,Antifungal,PD-1/PD-L1

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Cytochromes P450,Others,Antifungal,PD-1/PD-L1