CYP1B1-IN-5

SKU: orb1744477

Description

CYP1B1-IN-5 is a highly selective and potent inhibitor of cytochrome P450 1B1, exhibiting an IC50 value of 4.7 nM. This compound is a valuable research tool for investigating CYP1B1's role in metabolism-related diseases, including cancer chemoprevention and drug metabolism studies, in both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 176442-56-1
• MW: 349.12
• Purity: 98.61% (May vary between batches)
• Formula: C₁₄H₈INO₂
• SMILES: O=C1OC(=NC=2C1=CC=CC2)C3=CC=C(I)C=C3
• Target: Cytochromes P450
• Solubility: DMSO:5.63 mg/mL (16.13 mM)

Bioactivity

• Target IC50:
  CYP1A1:190.7 nM|CYP1B1:4.7 nM|CYP1A2:585.7 nM
• In Vitro:
  CYP1B1-IN-5 (Compound 6q) engages the CYP1B1 binding pocket through π-π stacking interactions with residues Phe231, Phe134, and heme.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CYP1B1

Compound Identifiers

PubChem CID

918856