CYP1B1-IN-4

SKU: orb1744478

Description

CYP1B1-IN-4 is a potent and selective 2,4-diarylthiazole inhibitor of cytochrome P450 1B1 (IC50=0.2 nM). It demonstrates low cytotoxicity and high metabolic stability in liver microsomes, making it a valuable chemical probe for investigating CYP1B1's role in cancer and xenobiotic metabolism in both cellular and animal studies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2685779-55-7
• MW: 322.38
• Purity: 98.74% (May vary between batches)
• Formula: C₁₈H₁₄N₂O₂S
• SMILES: O(C)C1=C(C2=NC(=CS2)C3=CC=C(C#N)C=C3)C=CC(OC)=C1
• Target: Cytochromes P450
• Solubility: DMSO:8 mg/mL (24.82 mM)

Bioactivity

• Target IC50:
  CYP1B1:0.2 nM|CYP1A1:3.98 μM
• In Vitro:
  CYP1B1-IN-4 (Compound 15) (1 nM-10 μM) inhibits CYP1A1 with an IC50 of 3.82 μM. Cyp1b1-IN-4 (100 μM; 72 h) is non-cytotoxic to HEK293 cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CYP1B1

Compound Identifiers

PubChem CID

160793266