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CYP1B1-IN-14 TFA

SKU: orb3210495

Description

CYP1B1-IN-14 TFA is a metabolically stable competitive inhibitor of hCYP1B1, with an IC50 of 1.32 nM and a Ki of 0.72 μM. It can reverse cancer cell resistance to Paclitaxel and works synergistically with Paclitaxel to inhibit tumor growth in xenograft models without significant toxicity. This compound is applicable in studies of cancers such as taxol-resistant lung cancer.

Images & Validation

Key Properties

TargetCytochromes P450,P-gp

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information