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CYP1B1-IN-12

SKU: orb3173271

Description

CYP1B1-IN-12 is a selective inhibitor of cytochrome P4501B1 (CYP1B1) with an IC50 value of 6.05 nM. It demonstrates exceptional selectivity, being over 1,600 times more selective for CYP1B1 compared to CYP1A1 and over 16,000 times compared to CYP1A2. CYP1B1-IN-12 enhances Paclitaxel-mediated apoptosis and restores sensitivity of A549/Tax cells to Paclitaxel. It also inhibits epithelial-mesenchymal transition, reducing cell migration and invasion. CYP1B1-IN-12 is applicable in cancer research, such as non-small cell lung cancer (NSCLC).

Research Area

Cell Biology, Metabolism Research

Images & Validation

Key Properties

TargetApoptosis,Cytochromes P450

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

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Protocol Information