CYP17-IN-1

SKU: orb1709953

Description

CYP17-IN-1 is a potent and orally bioavailable small molecule inhibitor of cytochrome P450 17A1 (CYP17). It demonstrates strong inhibitory activity in both in vitro assays and in vivo models, with IC50 values of 15.8 nM in rats and 20.1 nM in humans. This compound is a valuable research tool for studying androgen biosynthesis in prostate cancer and related endocrine disorders.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2093317-51-0
• MW: 312.4
• Purity: 99.83% (May vary between batches)
• Formula: C₁₈H₁₇FN₂S
• SMILES: FC=1C=C2C3=C(SC2=CC1)CN(CC=4C(C)=CC=NC4)CC3
• Target: Cytochromes P450
• Solubility: DMSO:3.13 mg/mL (10.02 mM)

Bioactivity

• Target IC50:
  CYP17 (rat):15.8 nM |CYP17 (human):20.1 nM
• In Vivo:
  CYP17-IN-1 dose-dependently reduced plasma testosterone levels in Sprague-Dawley rats.
• In Vitro:
  The IC50 value of CYP17-IN-1 for CYP3A4 is 8.5 µM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Human CYP17, CYP17IN1, CYP-17-IN-1, CYP17-IN-1, CYP17 IN 1, CYP17, Rat CYP17

Compound Identifiers

PubChem CID

137635843