Cynomolgus Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein, His Tag&Tag Free

• Catalog Number: orb1786194
• Category: Proteins
• Description: Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Also, Integrin alpha-V/beta-3 acts as a receptor for herpes virus 8/HHV-8, coxsackievirus A9, Hantaan virus, cytomegalovirus/HHV-5, human metapneumovirus, human parechovirus 1 and west nile virus. Furthermore, in case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
• Reactivity: Monkey
• Tag: C-10×His | Native
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 113 kDa & 81.7kDa
• Target: Integrin alpha V beta 3
• Source: Cynomolgus Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein, His Tag&Tag Free (orb1786194) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Pro 993 & Gly 27 - Asp 718 (Accession # A0A2K5WCD3-1 & A0A2K5WYN9).
• Expression System: HEK293
• Expression Region: Phe 31 - Pro 993 & Gly 27 - Asp 718
• Endotoxins: 1.0 EU per μg
• Storage: -20°C
• Buffer/Preservatives: 50 mM Tris, 150 mM NaCl, pH 8.0
• Note: For research use only
• Application notes: Cynomolgus Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAV and ITGB3, has a calculated MW of 113 kDa (ITGAV) and 81.7 kDa (ITGB3). The protein migrates as 90 kDa and 150 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.