Cynomolgus IL-23 R Protein

SKU: orb1496206

Description

Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

Research Area

Immunology & Inflammation

Images & Validation

• Application Notes:
  This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 64.5 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

• Source: Cynomolgus IL-23 R, Fc Tag (orb1496206) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Asp 353 (Accession # G7NWY5).
• Expression System: HEK293
• Target: IL-23 R
• Reactivity: Monkey
• Tag: C-Fc
• Expression Region: Gly 24 - Asp 353
• Endotoxins: 1.0 EU per μg
• Conjugation: Unconjugated
• MW: 64.5 kDa
• Purity: 95%

Storage & Handling

• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Form/Appearance: Liquid
• Buffer/Preservatives: PBS, pH7.4
• Expiration Date: 6 months from date of receipt.
• Dry Ice Shipping: Please note: This product requires shipment on dry ice. A dry ice surcharge will apply.
• Disclaimer: For research use only

Alternative Names

IL-23 R,IL-23 Receptor

Quick Database Links

Gene Symbol

IL-23 R

UniProt

G7NWY5

RefSeq:G7NWY5