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Catalog Number | orb1743005 |
---|---|
Category | Proteins |
Description | The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. IL-12 R beta 1 (Interleukin-12 receptor subunit beta-1) is also known as IL-12RB1, CD212. Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. |
Reactivity | Monkey |
Tag | C-Fc |
Form/Appearance | Powder |
Purity | 95% |
Conjugation | Unconjugated |
MW | 83.9 kDa |
Target | IL-12 R beta 1 |
Source | Cynomolgus IL-12 R beta 1 Protein, Fc Tag (orb1743005) is expressed from human 293 cells (HEK293). It contains AA Cys 24 - Asp 545 (Accession # G7PWY9-1). |
Expression System | HEK293 |
Biological Activity | Immobilized Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag at 5 μg/mL (100 μL/well) can bind Cynomolgus IL-12 R beta 1 Protein, Fc Tag with a linear range of 1-78 (QC tested). |
Expression Region | Cys 24 - Asp 545 |
Endotoxins | 1.0 EU per μg |
Storage | -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower. |
Buffer/Preservatives | PBS, pH 7.4 |
Note | For research use only |
Application notes | This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 83.9 kDa. The protein migrates as 110-120 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Expiration Date | 6 months from date of receipt. |
Immobilized Human IL-12B & IL-12A Heterodimer Protein, His Tag & Flag Tag at 5 μg/mL (100 μL/well) can bind Cynomolgus IL-12 R beta 1 Protein, Fc Tag (Cat. No. orb1743005) with a linear range of 1-78 (QC tested).
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