Cynomolgus CD39 Protein, His Tag (active enzyme, MALS verified)

SKU: orb1806472

Description

CD39 is also known as Ectonucleoside triphosphate diphosphohydrolase 1, ENTPD1, NTPDase 1, Ecto-ATPDase 1, in the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. NTPDase-1 was originally described as CD39, a B lymphocyte cell surface marker, but it is also present on the surface of natural killer cells, T cells, and some endothelial cells.Regulatory T cells(Tregs) mediate immunosuppression through multiple, non-redundant, cell-contact dependent and independent mechanisms, a growing body of evidence suggests an important role for the CD39-CD73-adenosine pathway. CD39 ectonucleotidase is the rate-limiting enzyme of a cascade leading to the generation of suppressive adenosine that alters CD4 and CD8 T cell and natural killer cell antitumor activities.

Research Area

Neuroscience; Immunology & Inflammation

Images & Validation

• Application Notes:
  This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 52.3 kDa. The protein migrates as 65-80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

• Source: Cynomolgus CD39 Protein, His Tag is expressed from CHO cells. It contains AA Thr 60 - Val 500 (Accession # XP_015311944.1).
• Expression System: CHO
• Target: CD39
• Reactivity: Monkey
• Tag: C-10×His
• Expression Region: Thr 60 - Val 500
• Endotoxins: 1.0 EU per μg
• Conjugation: Unconjugated
• MW: 52.3 kDa
• Purity: 95%

Storage & Handling

• Storage: -70°C
• Form/Appearance: Liquid
• Buffer/Preservatives: 20 mM Tris, 150 mM NaCl, 20% Glycerol, pH 8.0
• Expiration Date: 6 months from date of receipt.
• Dry Ice Shipping: Please note: This product requires shipment on dry ice. A dry ice surcharge will apply.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CD39

UniProt

XP_015311944.1

RefSeq:XP_015311944.1