CYM50308

SKU: orb1308415

Description

CYM50308

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1345858-76-5
• MW: 405.46
• Purity: 99.77%
• Formula: C₂₀H₂₁F₂N₃O₂S
• SMILES: COCC\N=C1/S\C(=C/c2cc(C)n(c2C)-c2ccc(F)cc2F)C(=O)N1C
• Target: LPL Receptor,S1P Receptor
• Solubility: DMSO:1 mg/mL (2.47 mM)

Bioactivity

• Target IC50:
  S1P5:2100 nM（EC50）|S1P4:（EC50）56 nM
• In Vitro:
  CYM50308 shows low nanomolar S1P4-R agonist activity and exquisite selectivity over the other S1P-Rs subtypes. CYM50308 provides a valuable pharmacological tool to explore the effects of the S1P4-R signaling cascade and elucidate the molecular basis of the in vivo receptor function.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CYM50308, CYM-50308, CYM 50308, inhibit, ML 248, ML248, ML-248, Lysophospholipid Receptor, LPLReceptor, LPL Receptor, LPL, Inhibitor, receptor, Potent, selective, S1PReceptor, S1P4, S1P4-R, S1P5, S1P5-R, S1P Receptor

Compound Identifiers

PubChem CID

49835928