CYM50260

SKU: orb1218898

Description

CYM50260 is an exquisitely agonist of sphingosine-1-phosphate 4 receptor (S1P4-R) (EC50: 45 nM). CYM50260 shows no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R.

Key Properties

• CAS Number: 1355026-60-6
• MW: 350.6
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₁Cl₃FNO₂
• SMILES: FCC1=CC=C(OCCOC2=CC=C(Cl)C=C2Cl)C(Cl)=N1
• Target: S1P4-R
• Solubility: In Vitro: DMSO : 125 mg/mL (356.53 mM)

Bioactivity

• In Vitro:
  CYM50260 (Compound 22aa) is a synthetic S1P4-R agonist. CYM50260 is found 3.5-fold more potent than the hit compound (HTS-hit). CYM50260 suppresses the collagen-stimulated platelet aggregation, PDGF-AB secretion and sCD40 L release. CYM50260 reduces the release of phosphorylated-HSP27 by collagen as well as the phosphorylation of HSP27.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

S1P4-R