CYM5541

SKU: orb1303511

Description

CYM-5541

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 945128-26-7
• MW: 316.44
• Purity: >98%
• Formula: C₁₉H₂₈N₂O₂
• SMILES: O=C(N(C1CCCCC1)C1CCCCC1)c1cc(on1)C1CC1
• Target: GPCR
• Solubility: Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 15 mg/ml)

Bioactivity

• Target IC50:
  S1P3:72-132 nM(EC50)
• In Vitro:
  CYM-5541 is a full agonist that achieves maximal ERK phosphorylation levels comparable to S1P, with an EC50 of 72-132 nM and high selectivity over other S1P receptor subtypes: S1P1 EC50 >10 μM, S1P2 EC50 >50 μM, S1P4 EC50 >50 μM, and S1P5 EC50 >25 μM. It exhibits no significant activity in the Ricerca profiling panel of 55 GPCRs, ion channels, and transporters. CYM-5541 enabled the identification of an allosteric site, with residue F263 being crucial for its affinity and efficacy, suggesting the presence of a unique hydrophobic pocket responsible for its S1P3 selectivity .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ML249

Compound Identifiers

PubChem CID

17253208