Cyfluthrin

SKU: orb1303774

Description

Cyfluthrin is a pyrethroid insecticide that acts by binding to and modifying the gating kinetics of voltage-gated sodium channels, such as Nav1.8. This action disrupts neuronal signaling, making it a valuable research tool for neurotoxicology and insecticide mechanism studies in both in vitro and in vivo models.

Research Area

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 68359-37-5
• MW: 434.29
• Purity: 99.76% (May vary between batches)
• Formula: C₂₂H₁₈Cl₂FNO₃
• SMILES: C(OC(C#N)C1=CC(OC2=CC=CC=C2)=C(F)C=C1)(=O)C3C(C=C(Cl)Cl)C3(C)C
• Target: Sodium Channel,Reactive Oxygen Species
• Solubility: DMSO:55 mg/mL (126.64 mM);Chloroform:Slightly soluble

Bioactivity

• Target IC50:
  ROS:19.39 μM
• In Vitro:
  Cell viability MTT assay was carried out to assess cyfluthrin cytotoxicity; IC30 and IC50 values for cyfluthrin were calculated to be 4.81 ± 0.92 μM and 19.39 ± 3.44 μM, respectively. Cyfluthrin increased significantly gene expressions of apoptosis, proinflammation and oxidative stress (Bax, Bcl-2, Casp-3, BNIP3, AKT1, p53, APAF1, NFκB1, TNFα and Nrf2) mediators. In the most genes, the mRNA levels induced by cyfluthrin were partially reduced by MEL (1 μM).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Reactive Oxygen Species, ReactiveOxygenSpecies, SodiumChannel, Sodium Channel, veterinary medicine,agriculture, insecticide,stored product, Inhibitor, grasshopper,pest,pyrethroid, Nav1.8 channel, Na channels, Na+ channels, inhibit, Cyfluthrin

Compound Identifiers

PubChem CID

104926