You have no items in your shopping cart.
You have no items in your shopping cart.
Catalog Number | orb1306329 |
---|---|
Category | Small Molecules |
Description | Cyclosporin H |
CAS Number | 83602-39-5 |
Purity | 99.87% |
MW | 1202.61 |
SMILES | [C@H]([C@@H](C/C=C/C)C)(O)[C@@]1(N(C)C(=O)[C@@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H]([C@H](C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC1=O)[H] |
Formula | C62H111N11O12 |
Biological Activity | Cyclosporin H (CsH), a specific inhibitor of FPR1, inhibited lung inflammation in the ALI models. CsH significantly attenuated MTDs or NFP-induced inflammatory lung injury and activation of MAPK and AKT pathways. Cyclosporin H is a viral transduction enhancer which increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). When combined with Rapamycin or Prostaglandin E2 Cyclosporin H displays an additive effect. Cyclosporin H lacks immunosuppressant activity of Cyclosporin A. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
Filter by Rating