Cyclosporin H

SKU: orb1306329

Description

Cyclosporin H is a specific FPR1 inhibitor that attenuates inflammatory lung injury in ALI models by suppressing MAPK and AKT pathways. It also serves as a potent lentiviral transduction enhancer in hematopoietic stem cells and exhibits additive effects when combined with Rapamycin or PGE2, all without the immunosuppressive activity of Cyclosporin A.

Key Properties

• CAS Number: 83602-39-5
• MW: 1202.61
• Purity: 99.94% (May vary between batches)
• Formula: C₆₂H₁₁₁N₁₁O₁₂
• SMILES: C\C=C\C[C@H](C)[C@H](O)C1N(C)C(=O)[C@@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)CCCNC1=O)C(C)C
• Target: Others
• Solubility: DMSO:99 mg/mL (82.32 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (2.74 mM)

Bioactivity

• Target IC50:
  FMLP:0.1 μM (ki)
• In Vivo:
  Cyclosporin H, administered intraperitoneally (i.p.) at a dosage of 5 mg/kg prior to challenge with LPS or HCl, mitigates lung injury caused by LPS or HCl in a lung injury model.
• In Vitro:
  Cyclosporin H is a potent inhibitor of FMLP-induced superoxide anion (O2-) formation in human neutrophils. Cyclosporin H inhibited FMLP binding in HL-60 membranes with a Ki (inhibition constant) of 0.10 μM. Cyclosporin H inhibited activation by FMLP of high affinity GTPase (the enzymatic activity of alpha-subunits of heterotrimeric regulatory guanine nucleotide-binding proteins) in HL-60 membranes with a Ki of 0.79 μM. Cyclosporin H inhibited the stimulatory effects of FMLP on cytosolic Ca2+ concentration ([Ca2+]i), O2- formation, and beta-glucuronidase release with Ki values of 0.08, 0.24, and 0.45 μM, respectively.

Storage & Handling

• Storage: keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cyclosporin H, inhibit, FPR1, lentiviral, Inhibitor, transduction, viral

Compound Identifiers

PubChem CID

51340731