Cyclo(Pro-Ala)

SKU: orb1297044

Description

Cyclo(Pro-Ala) is a naturally occurring cyclic dipeptide, or diketopiperazine. It serves as a valuable research tool in microbiology and pharmacology, with studies exploring its antimicrobial and signaling properties in both in vitro and in vivo experimental models.

Key Properties

• CAS Number: 65556-33-4
• MW: 168.19
• Purity: 99.45% (May vary between batches)
• Formula: C₈H₁₂N₂O₂
• SMILES: CC1NC(=O)C2CCCN2C1=O
• Target: Others
• Solubility: DMSO:11 mg/mL (65.4 mM)

Bioactivity

• In Vitro:
  To find the cell cycle inhibitors from the metabolites of Streptomyces flavoretus 18522. METHODS AND RESULTS: Activity-guided isolation was performed on the chloroform extract of the fermentation broth and mycelia of Streptomyces flavoretus 18522 by using ts FT210 cells.Compounds were isolated through various chromatoghraphic methods and elucidated by spectroscopic means.The flow cytometry was used to evaluate the cell cycle inhibiting activity of the fractions and compounds. Six cyclic dipeptides were obtained and identified as cyclo(Ala-Leu)(1),cyclo(Ala-Ile)(2),cyclo(Ala-Val)(3),cyclo(Phe-Leu)(4),Cyclo(Pro-Ala)(5) and cyclo(Phe-Val)(6). CONCLUSIONS: Compounds 1-6 are reported as new cell cycle inhibitors for the first time.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cyclo(Pro Ala), Cyclo(ProAla), Cyclo(Pro-Ala)

Compound Identifiers

PubChem CID

6428987