Cyclopiazonic acid

SKU: orb1308419

Description

Cyclopiazonic acid (CPA) is a neurotoxic secondary metabolite from Aspergillus flavus that acts as a potent nanomolar inhibitor of the sarco/endoplasmic reticulum Ca²⁺ ATPase (SERCA). It is widely used in research to study calcium signaling, ER stress, and programmed cell death in both in vitro cellular models and in vivo plant studies.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 18172-33-3
• MW: 336.38
• Purity: >98%
• Formula: C₂₀H₂₀N₂O₃
• SMILES: [H][C@@]12Cc3cccc4[nH]cc(c34)[C@]1([H])[C@]1([H])N(C(O)=C(C(C)=O)C1=O)C2(C)C
• Target: ATPase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.89 mM);DMSO:100 mg/mL (297.28 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cyclopiazonic acid, Calcium Channel, CalciumChannel, Ca2+ATPase, Ca channels, Ca2+ channels, inhibit, Inhibitor

Compound Identifiers

PubChem CID

54682463