Cycloheximide

SKU: orb1941022

Description

Cycloheximide (Naramycin A, Actidione) is a widely-used protein synthesis inhibitor that inhibits protein biosynthesis in eukaryotic organisms with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively; block the elongation phase of eukaryotic translation, binds the ribosome and inhibits eEF2-mediated translocation; impairs memory more as footshock intensity increases, enhances memory in an inverted-U dose-response manner at low dose; also sensitizes COLO 205 cells to TNF-alpha-induced programmed cell death.

Key Properties

• CAS Number: 66-81-9
• MW: 281.3474
• Purity: >98% (HPLC)
• Formula: C₁₅H₂₃NO₄
• SMILES: O=C(CC(C[C@H]([C@H]1C([C@@H](C)C[C@H](C)C1)=O)O)C2)NC2=O
• Target: DNA/RNA Synthesis
• Solubility: DMSO: >33 mg/mL; H2O: 20 mg/mL (Need ultrasonic and warming)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Naramycin A | Actidione

Quick Database Links

Gene Symbol

DNA/RNA Synthesis