α-Cyclodextrin

SKU: orb1307591

Description

Alfadex (α-Cyclodextrin) is a corn-derived soluble fiber studied for its role in weight management, particularly in obese type 2 diabetic models. Research applications include in vitro binding assays and in vivo studies investigating its effects on lipid metabolism and glucose homeostasis.

Research Area

Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 10016-20-3
• MW: 972.84
• Purity: 98.27% (May vary between batches)
• Formula: C₃₆H₆₀O₃₀
• SMILES: C(O)[C@@H]1[C@@]2([C@H](O)[C@@H](O)[C@](O1)(O[C@@]3([C@@H](CO)O[C@@]([C@H](O)[C@H]3O)(O[C@@]4([C@@H](CO)O[C@@]([C@H](O)[C@H]4O)(O[C@]5([C@H](O)[C@@H](O)[C@@](O[C@]6([C@H](O)[C@@H](O)[C@@](O[C@]7([C@H](O)[C@@H](O)[C@@](O2)(O[C@@H]7CO)[H])[H])(O[C@@H]6CO)[H])[H])(O[C@@H]5CO)[H])[H])[H])[H])[H])[H])[H])[H]
• Target: Others
• Solubility: DMSO:100 mg/mL (102.79 mM);H2O:40 mg/mL (41.12 mM)

Bioactivity

• In Vivo:
  α-Cyclodextrin preferentially reduces blood levels of saturated and trans fats in the LDL receptor knockout mice. Two independent in vivo biological test systems were used, a single cell Xenopus oocyte with expressed human aquaporin for cell hydration studies and the nematode Caenorhabditis elegans for testing life span in the treated animals. α-Cyclodextrin was found to enhance water uptake through aquaporins of oocytes. Furthermore, α-Cyclodextrin promoted longevity in C. elegans.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

a-Cyclodextrin, alpha-Cyclodextrin, Alfadex, Inhibitor, NSC 269470, inhibit, NSC269470, NSC-269470, α Cyclodextrin, αCyclodextrin, α-Cyclodextrin

Compound Identifiers

PubChem CID

444913