Cyclizine dihydrochloride

SKU: orb1221997

Description

Cyclizine Dihydrochloride is a histamine H1 antagonist. It is given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 5897-18-7
• MW: 339.3
• Purity: >98% (HPLC)
• Formula: C₁₈H₂₄Cl₂N₂
• SMILES: CN1CCN(CC1)C(c1ccccc1)c1ccccc1.Cl.Cl
• Target: H1 receptor

Bioactivity

• In Vivo:
  Cyclizine (1, 10 mg/kg) dihydrochloride enhances locomotor activity of mice in a dose-dependent manner. Animal model: Naive male CDI mice (Charles River) weighing 25-30 g. Dosage: 1, 10 mg/kg. Administration: s. c. ; locomotor activity (crossings) measured every 15 min for 2 hr. Result: Enhanced locomotor activity in a dose-dependent manner.
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• In Vitro:
  Cyclizine (100 μM) dihydrochloride significantly inhibits nitrite accumulation and iNOS protein levels in the LPS-stimulated in RAW 264.7 cells supernatants. Cyclizine dihydrochloride inhibits anti-IgE-induced histamine release from isolated human lung fragments, with an IC50 of 5.42 μM.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

H1 receptor