Cyanostatin B

SKU: orb3180353

Description

Cyanostatin B, a lipopeptide derived from cyanobacteria, acts as a leucine aminopeptidase (LAP) inhibitor with an IC50 of 12 ng/mL. It exhibits weak inhibitory effects on protein phosphatase (PP2A) and angiotensin-converting enzyme (ACE), with an IC50 of 130 μg/mL. While Cyanostatin B shows no toxicity to brine shrimp, it demonstrates cytotoxicity and genotoxicity in human liver cells in vitro. Furthermore, Cyanostatin B inhibits the proliferation of HepG cells, induces DNA single-strand breaks, and causes genomic instability.

Key Properties

• Target: DNA/RNA Synthesis,Aminopeptidase,Phosphatase,Angiotensin-converting Enzyme (ACE)
• CAS Number: 850131-23-6
• MW: 753.94
• Formula: C₄₀H₅₉N₅O₉
• SMILES: C([C@@H](N(C([C@H](CC1=CC=C(O)C=C1)NC([C@H]([C@@H](CCCCCCC)N)O)=O)=O)C)[C@H](CC)C)(=O)N2[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(O)=O)=O)CCC2

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DNA/RNA Synthesis,Aminopeptidase,Phosphatase,Angiotensin-converting Enzyme (ACE)