CXD101

SKU: orb1301866

Description

CXD101 is a novel, class I-selective histone deacetylase inhibitor (HDACi) with potent activity against HDAC1, HDAC2, and HDAC3, while exhibiting no inhibition of class II HDACs. This selectivity profile makes it a valuable research tool for investigating epigenetic mechanisms in oncology, with demonstrated utility in both in vitro and in vivo cancer models.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 934828-12-3
• MW: 403.52
• Purity: 99.82% (May vary between batches)
• Formula: C₂₄H₂₉N₅O
• SMILES: Cc1nn(C)cc1CN1CCC(CC1)c1ccc(cc1)C(=O)Nc1ccccc1N
• Target: HDAC
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (4.96 mM);DMSO:31 mg/mL (76.82 mM)

Bioactivity

• Target IC50:
  HDAC3:550 nM |HDAC1:63 nM |HDAC2:570 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

acetylation, antitumor, CXD 101, CXD101, CXD-101, inhibit, orally, Inhibitor, HDAC, HDAC3, HDAC1, HDAC2, Histone deacetylases, histone

Compound Identifiers

PubChem CID

16225380