CXCR2-IN-1

SKU: orb1709969

Description

CXCR2-IN-1 is a potent, brain-penetrant CXCR2 antagonist with a pIC50 of 9.3. This small molecule is a valuable research tool for investigating the role of CXCR2 in neuroinflammation, both in cellular assays and in vivo central nervous system disease models.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1873376-49-8
• MW: 476.35
• Purity: 99.89% (May vary between batches)
• Formula: C₁₉H₂₀Cl₂FN₃O₄S
• SMILES: CN1CCC(CC1)S(=O)(=O)c1c(Cl)ccc(NC(=O)Nc2cccc(F)c2Cl)c1O
• Target: CXCR
• Solubility: DMSO:4.5 mg/mL (9.45 mM)

Bioactivity

• Target IC50:
  CXCR2:9.3(pIC50)
• In Vivo:
  CXCR2-IN-1 has shown efficacy in oral copper ketone-induced demyelination models by oral administration, providing evidence to support CXCR2 as a potential therapeutic target for the treatment of demyelinating diseases such as multiple sclerosis.
  Read more...
• In Vitro:
  CXCR2 is crucial for activating and recruiting neutrophils to inflammation sites. CXCR2-IN-1 demonstrated favorable central nervous system penetration (Br/Bl>0.45) .
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CXCR2, CXCR2 IN 1, CXCR2IN1, CXCR-2-IN-1, CXCR2-IN-1

Compound Identifiers

PubChem CID

127020968