CX-6258 hydrochloride

SKU: orb1688556

Description

CX-6258 hydrochloride

Research Area

Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 1353859-00-3
• MW: 498.4
• Purity: 96.03%
• Formula: C₂₆H₂₄ClN₃O₃·HCl
• SMILES: Cl.CN1CCCN(CC1)C(=O)c1cccc(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1
• Target: Pim
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.01 mM);H2O:82 mg/mL (164.53 mM);DMSO:97 mg/mL (194.62 mM);Ethanol:1 mg/mL (2.01 mM)

Bioactivity

• Target IC50:
  Pim3:16 nM|Pim1:5 nM|Pim2:25 nM
• In Vivo:
  In mice carrying MV-4-11 xenografts, CX-6258 dose-dependently suppresses the tumor growth , with a 50/100 mg/kg dose producing 45%/75% tumor growth inhibition.
• In Vitro:
  CX-6258 has anti-proliferative activity against a panel of human cancer cell lines (IC50: 0.02-3.7 μM), mostly sensitive to acute leukemia cell lines. Combinations of CX-6258 with doxorubicin (10:1 molar ratio) and CX-6258 with paclitaxel (100:1 molar ratio) produces synergistic cell killing (CI50: 0.4 and 0.56).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pim, Pim2, Pim1, Pim kinases, Pim3, Pim-Kinase Inhibitor X, inhibit, Inhibitor, CX6258, CX-6258, CX-6258 HCl, CX6258 hydrochloride, CX6258 Hydrochloride, CX-6258 Hydrochloride, CX 6258, CX 6258 Hydrochloride, CX 6258 hydrochloride, Bad, 4E-BP1

Compound Identifiers

PubChem CID

72201040