CWP232228

SKU: orb1309804

Description

CWP232228

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1144044-02-9
• MW: 717.63
• Purity: 98.87% (May vary between batches)
• Formula: C₃₃H₃₄N₇Na₂O₇P
• SMILES: O=C(NCC1=CC=CC=C1)N(N(CC2=O)CC=C)[C@]([H])(N2[C@H](C3=O)CC4=CC=C(C=C4)OP([O-])([O-])=O)CN3CC5=CC=CC6=CN(N=C56)C.[Na+].[Na+]
• Target: Wnt/beta-catenin
• Solubility: H2O:60 mg/mL (83.61 mM)

Bioactivity

• In Vivo:
  CWP232228 (100 mg/kg, administered i.p.; daily; mice with 4T1 cell tumors for 21 days; mice with MDA-MB-435 cell tumors for 60 days) significantly reduced tumor volume.
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• In Vitro:
  CWP232228 (0.01-100 μM; 48 hours) inhibited cell proliferation, with IC50 values of 2 μM in mouse (4T1) and 0.8 μM in human (MDA-MB-435) breast cancer cell lines. In Hep3B, Huh7, and HepG2 cells, CWP232228 (0.01-10 μM; 48 hours) demonstrated IC50 values of 2.566, 2.630, and 2.596 μM, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cells, Breast, beta-catenin, betacatenin, Beta catenin, CWP 232228, CWP232228, CWP-232228, Cancer, bcatenin, liver, inhibit, Inhibitor, stem, Wnt, Wnt/betacatenin, Wnt/b-catenin, signaling, Wnt/β-catenin, βcatenin, β-catenin

Compound Identifiers

PubChem CID

71509158